The top Synthetic Issuer projects, ranked by prominence — TVL, market cap, funding, and on-chain activity.

Synthetix
CEX-like perpetual futures on Ethereum.
arbitrumavalanchebase+7

Metronome
First autonomous cross-chain cryptocurrency
baseethereumoptimism

AWE Network
Portal to Autonomous Worlds for AI Agents
baseethereum

Horizon Protocol
defunctTrade synthetic real-world assets on BNB Chain
bnb-chain

DAFI Protocol
Trade Without Limits on the Hybrid Exchange
bnb-chainethereumpolygon

UMA
Priceless DeFi contracts for universal access
arbitrumavalancheethereum

Mettalex
Zero-slippage DEX powered by AI agents.
bnb-chainethereum

Cryptex Finance
Synthetic indexes governed by the community
baseethereum

Indigo Protocol
Autonomous synthetics for real-world assets on Cardano
cardano

Offshift
Private DeFi on Ethereum L1
bnb-chainethereum

Mirror Protocol
bnb-chainethereumterra-classic

Jarvis
arbitrumbasebnb-chain+4

Jarvis Reward
arbitrumavalanchebnb-chain+3

Selenium
terra-classic